Verbund FTD

Publikationen

Die nachfolgende Liste zeigt ausschließlich Publikationen, die durch Mittel des KNDD direkt unterstützt wurden. KNDD Wissenschaftler - Laborleiter sowie Doktoranden und Postdoktoranden - sind fett unterlegt. 

  1. Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C (2009) Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J. Neurochem. 110:1082-1094.
  2. Neumann M (2009) Molecular neuropathology of TDP-43 proteinopathies. Int. J. Mol. Sci. 10:232-246. 
  3. Schebelle L, Wolf C, Stribl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, Wurst W, Floss T (2010) Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. Nucleic Acids Res. 38:e106. 
  4. Fiesel FC, Voigt A, Weber SS, Van den Haute C, Waldenmaier A, Görner K, Walter M, Anderson ML, Kern JV, Rasse TM, Schmidt T, Springer W, Kirchner R, Bonin M, Neumann M, Baekelandt V, Alunni-Fabbroni M, Schulz JB, Kahle PJ (2010) Knockdown of transactive response DNA-binding protein TDP-43 downregulates histone deacetylase 6. EMBO J. 29:209-221.
  5. Voigt A, Herholz D, Fiesel FC, Kaur K, Müller D, Karsten P, Weber SS, Kahle PJ, Marquardt T, Schulz JB (2010) TDP-43-mediated neuron loss in vivo requires RNA-binding activity. PLoS ONE 5:e12247
  6. Waibel S, Neumann M, Rabe M, Meyer T, Ludolph AC (2010) Novel missense and truncating mutations in FUS/TLS in familial ALS. Neurology 75:815-817.
  7. Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than M, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C (2010) ALS-associated fused in sarcoma (FUS) mutations disrupt transportin-mediated nuclear import. EMBO J. 29:2841-2857.
  8. Dormann, D. & Haass, C. (2011).  TDP-43 and FUS - a nuclear affair. Trends Neurosci. 7:339-348.
  9. Fiesel FC, Kahle PJ (2011) TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration. FEBS J. 278:3550-3568.
  10. Fiesel FC, Schurr C, Weber SS, Kahle PJ (2011) TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6. Mol. Neurodegener. 6:64.
  11. Fiesel FC, Weber SS, Supper J, Zell A, Kahle PJ (2011) TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR. Nucleic Acids Res. 40:2668-2682.
  12. Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang L-C, Bilbao J, Rademakers R, Haass C, Mackenzie IR (2011). FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain 134:2595-2609.
  13. Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass, C (2011). Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.  J. Neurosci. 31:1885-1894
  14. Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D, Haass C (2012) Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA binding protein of 43 kDa (TDP-43). J. Biol. Chem. 287:23079-23094.
  15. Dormann D, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C (2012) Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J. [Epub ahead of print]